The bHLH transcription factor hand is required for proper wing heart formation in Drosophila
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چکیده
منابع مشابه
Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.
The Hand gene family encodes highly conserved basic helix-loop-helix (bHLH) transcription factors that play crucial roles in cardiac and vascular development in vertebrates. In Drosophila, a single Hand gene is expressed in the three major cell types that comprise the circulatory system: cardioblasts, pericardial nephrocytes and lymph gland hematopoietic progenitors, but its function has not be...
متن کامل09-P078 Wing heart integrity depends on the cardiogenic transcription factor hand in Drosophila
09-P076 A rhombomere 4-derived auditory circuitry is dependent on Hoxb1 function Maria Di Bonito, Marta Mancuso, Gennaro Andolfi, Anna Maria Franz, Luigi Sequino, Luis Puelles, Michle Studer Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy Institute of Genetics and Biophysics, IGB A. Buzzati Traverso, Naples, Italy Universit degli Studi di Napoli Federico II, Naples, Italy Hea...
متن کاملThe bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster
Hand proteins belong to the highly conserved family of basic Helix-Loop-Helix transcription factors and are critical to distinct developmental processes, including cardiogenesis and neurogenesis in vertebrates. In Drosophila melanogaster a single orthologous hand gene is expressed with absence of the respective protein causing semilethality during early larval instars. Surviving adult animals s...
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In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...
متن کاملNato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse
The evolutionarily conserved basic helix-loop-helix (bHLH) transcription factors play important roles during development. Here we report the identification of Nato3 (nephew of atonal fer3) orthologs in Drosophila, C. elegans, mouse, and man, all of which share a high degree of similarity within the bHLH domain. Expression analysis revealed Nato3 transcripts in the central nervous system of both...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2013
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2013.05.027